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Systolic (SBP) and diastolic blood pressure (DBP) can both be decreased by exercise alone by about 3.5 and 2.0mm Hg, respectively

Cell Cycle 11 , 395406 (2012)

Unlike the large synthetic molecule semaglutide, orforglipron is a small molecule, though both act by mimicking GLP-1

Some GLP-1 agonists (particularly semaglutide) carry warnings about diabetic retinopathy complications

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J Med Chem 58:73707380 Lee TS, Park EJ, Choi M, Oh HS, An Y, Kim T, Kim TH, Shin BS, Shin S (2023) Novel LC-MS/MS analysis of the GLP-1 analog semaglutide with its application to pharmacokinetics and brain distribution studies in rats