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Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

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(3) inability to follow up regularly (4) known intolerance or hypersensitivity to GLP-1RA therapy, including significant gastrointestinal adverse reactions (such as persistent nausea, vomiting, or diarrhea) or severe hypoglycemic episodes that would preclude continued use of the drug

NEJM Full Text Jastreboff, A.M., et al