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Additionally, free heme can generate the reactive nitrogen species peroxynitrite that can further oxidative stress 61

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Furthermore, intracellular Fe 2+ is pumped into the extracellular space through membrane ferritin 1 (SLC40A1/FPN1) to strictly maintain cellular iron homeostasis ( Many studies have demonstrated that iron metabolism-related proteins could be used as targets to regulate ferroptosis

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Semaglutide's once-weekly pharmacology depends on maintaining steady blood levels