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Tesfay, L
Amylin/Pramlintide Combinations Previous animal studies have shown that amylin treatment significantly enhanced hypothalamic anorexigenic leptin signaling, while the combination treatment with amylin and leptin led to marked, synergistic reductions in food intake (up to 45%) and fat-specific weight loss (up to 15%)
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These coactivators generally orchestrate with DNA-bound transcription factors, such as nuclear respiratory factors (NRF1, NRF2), estrogen-related receptors (ERR, ERR, and ERR), and myocyte enhancer factor 2 (MEF2) to drive the expression of target genes
Values summarised from cited preclinical studies (see references below)
As well as helping modulate inflammation, there is some evidence that the peptide can have activity against certain microbes
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