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Most patients continue their metformin while starting semaglutide or tirzepatide at a lower dose, then titrate upward over several weeks
A: Compounded estrogen preparations use the same bioidentical hormones (estradiol, estriol) found in FDA-approved products, but they are custom-prepared by compounding pharmacies and are not FDA-approved
GLP-1 itself exemplifies this phenomenon, as early native peptide formulations required continuous infusion to achieve sustained efficacy
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