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An immunologic basis for the genesis and progression of endometriosis is already theorized and IL-8 is one of the known key proinflammatory cytokines in this process, and fibrosis in general, he noted

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In the physiological state, it is localized in the cell cytosol and is regulated by a variety of protein translational modifications (PTMs) to adapt to different cellular environments, such as phosphorylation, ubiquitination, S-nitrosylation, palmitoylation, and SUMOylation (Jin et al., 2021)