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Negative Feedback Regulation Importantly, Sermorelin stimulation is subject to physiological regulation through the somatostatin-GHRH axis: when GH and IGF-1 levels rise, this triggers negative feedback at the hypothalamus, stimulating release of somatostatin (also called growth hormone-inhibiting hormone or GHIH) from periventricular hypothalamic neurons

90 Farwell AP

Brain ferritin iron may influence age- and gender-related risks of neurodegeneration

doi: 10.4161/viru.23987

Thankfully, more often than not, Life Extension makes its science clear

This allows for the medication to be absorbed through the oral mucosa, providing targeted local or systemic effects