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Available human data comprises primarily small studies

Cyclophosphamide induced stomach and duodenal lesions as a NO-system disturbance in rats: L-NAME, L-arginine, stable gastric pentadecapeptide BPC 157

[DOI] [PubMed] [Google Scholar] 50.Shobeiri P, Seyedmirzaei H, Karimi N, et al

Hormones like estrogen and progesterone stimulate melanocytes, leading to dark patches on sun-exposed areas, especially during pregnancy or with birth control

Then, drug components should keep soluble in the entire GI tract

Clostridium , a genus of anaerobic, Gram-positive, thick-walled bacteria, constitutes a dominant component of the healthy gut microbiota (35)