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eLife 10 , 67312 (2021)

Liu AX, He WH, Yin LJ, Lv PP, Zhang Y, Sheng JZ, Leung PC, Huang HF: Sustained endoplasmic reticulum stress as a cofactor of oxidative stress in decidual cells from patients with early pregnancy loss

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Nature 593 , 460464 (2021)

The chronic inflammatory environment degrades existing collagen faster than the body can replace it, and the disorganized keratinocyte proliferation further disrupts normal tissue structure

Two factors compound: drug exposure scales with body weight (lighter body = more drug per pound), and physiological response varies by metabolic and cardiovascular phenotype