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Han et al., 2015

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Studies such as LEADER, SUSTAIN-6, REWIND, SELECT, and most recently the SOUL trial demonstrated that certain GLP-1 receptor agonists were associated with reductions in major adverse cardiovascular events, including heart attack, stroke, and cardiovascular death.[4][5][6][7] Much of the semaglutide cardiovascular evidence, in particular, has shaped how doctors now think about these medicines