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Insulin plays a crucial role in this process by directly impacting theca cells, increasing androgen secretion, stimulating the release of plasminogen activator inhibitor-1, and inhibiting plasmin production

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Cardiovascular Disease

Cell lines and culture conditions HepG2 cells, a human hepatoma cell line, were obtained from the American Type Culture Collection (Manassas, VA) and were cultured in Dulbeccos modified Eagles medium (DMEM) containing 10% (v/v) fetal bovine serum, 2 mM glutamine, 5 U/mL penicillin, and 50 g/mL streptomycin at 37 C in a humidified O 2 /CO 2 (19:1) atmosphere

Mehrotra, D

Effect of highly bioaccumulated polychlorinated biphenyl congeners on estrogen and androgen receptor activity