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Blood 136 , 99 (2020)

Earlier SURMOUNT-1 data further reinforced these outcomes, with tirzepatide demonstrating weight loss of up to 22.5% of body weight over 72 weeks, the highest ever recorded for a pharmacological weight loss therapy at that time

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In summary, monocyte-derived macrophages from individuals with CD have increased susceptibility to H 2 O 2 -induced ferroptosis cell death, that may be facilitated, at least in part, by reduced expression of the antioxidant GPx1

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