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Reactive oxygen species: from harmful molecules to fine-tuning regulators of stem cell niche maintenance

The recent introduction (Aronson 2005) of omic technologies allows for exploration of miRNA, protein and metabolites and represents a potentially promising approach for the evaluation of new biomarkers of drug toxicity and will refine translational systems medicine

TI 07.003

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Researchers first isolated it from epithalamin, a substance extracted from the pineal gland

TME-mediated non-autonomous MDR mechanisms While intrinsic mechanisms provide a primary defense, the TME serves as a non-cell-autonomous collaborator that shapes the resistance phenotype