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in vitro , androgen excess induces peripheral insulin resistance and pancreatic -cell insulin hypersecretion in both female human and mouse cell culture models, predisposing to onset of -cell failure and T2DM (Navarro et al., 2018)

It also protects the surface of the skin and enhances the damaged or irritated skin barrier

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The safety and efficacy of citrus aurantium (bitter orange) extracts and p-synephrine: A systematic review and meta-analysis

observed that exosomes derived from mouse BMSCs significantly reduced inflammatory cytokines (IL-6, IL-1, TNF-) and decreased tissue damage and neutrophil infiltration

Oncogene 26(8):1201-1212, 2007