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The histamine molecule then binds to one of four different receptor typesH1, H2, H3, and H4located in different places and performing different functions throughout the body

10.1038/s41582-019-0244-7 30 HsuY

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But, this quicker action can cause irritation, particularly for those who have sensitive skin or underlying skin conditions such as eczema

10.1016/j.jaad.2012.12.781 9 ArtziO.HorovitzT.BarIlanE.ShehadehW.KorenA.ZusmanovitchL.et al (2021)

Through the FGF21SIRT1 axis, FGF21 may shift from a protective to a dysregulatory role, exacerbating hepatic lipid accumulation and metabolic imbalance in advanced disease stages