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They occur in both sexes especially in darker skin-colored individuals and the onset occurs in the fourth decade in most of the patients

81 Shaikh et al reported that dapagliflozin is a potent dual inhibitor of SGLT-2 and acetylcholinesterase, which could be used as the basis for future dual therapy for patients with diabetes and diabetes-related neurological disorders

Data availability Not applicable

darken significantly in summer Sit in the very top layer of skin (epidermis) Respond well to home remedies, topical serums, and light laser treatments 2

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Factors to consider include the type of cancer, time since treatment, current cancer status, and the potential benefits of therapy for diabetes control or weight loss