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Internal changes during this phase include upregulation of collagen genes, increased growth factor production, and early accumulation of new extracellular matrix components

A nano-lipid GHK formulation produced a 31.6% reduction in wrinkle volume at 8 weeks in a separate human trial (Pickart & Margolina, 2018)

Therefore, this pathway does not provide a basis for cosmetic market approval

Iles and Liu 2005

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found that caloric restriction further increased the lifespans of their GHRH knockout mice, indicating that at least some of the effects of caloric restriction are independent of disrupted growth hormone signaling