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The human metabolic models with all constraints for the blood medium and the viral replication reactions have been uploaded to the BioModels Database 93 (Table 3) under the following accessions: Dengue, Influenza, SARS-CoV-2 BALF1, SARS-CoV-2 BALF2, SARS-CoV-2 CALU3, SARS-CoV-2 scH1299, Figure source data can be found in Supplementary Data 3

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Herein, we found that children born to parents with obesity had increased fasting insulin levels and HOMA-IR scores, in agreement with previous clinical [32, 33] and experimental [10] studies describing that PO may disrupt cell development in the offspring, thus impairing insulin production and function