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[1] [2] As of mid-2025, retatrutide has not received approval from the MHRA or EMA and remains under clinical investigation (ClinicalTrials

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Fasting triglyceride levels at timepoint 1 were significantly increased in the low carnitine group compared to normal carnitine group

New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases

Important cautions include avoiding use in patients with severe gastroparesis or other severe gastrointestinal disease, monitoring for diabetic retinopathy complications (particularly in patients with pre-existing retinopathy), and avoiding use during pregnancy with a recommended washout period of at least 2 months before planned conception