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Eligible participants were 40-80 years of age and had mild-to-moderate COPD (forced expiratory volume in 1 second [FEV 1 ] to forced vital capacity ratio 0.05 for all comparisons of FEV 1 and FVC) (Fig

Integrin antagonists : Vedolizumab (Entyvio) and natalizumab (Tysabri) prevent lymphocyte trafficking to intestinal tissue, offering gut-selective anti-inflammatory effects