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Clinical guidelines often recommend these medications for people who have a body mass index (BMI) of 30 or higher, or for people with a BMI of 27 or higher if they also have weight-related health issues, such as diabetes or high blood pressure

[24] For many patients, long-term treatment may be medically appropriate as these medications are FDA-approved for chronic weight management

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The compound targets the Sec residue of the Gly-Cys-Sec-Gly active site motif of the human TrxR and irreversibly inhibits the enzyme ( S

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