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Moreover, NUAK1 inhibition causes tumor ICD through H 2 O 2 /OH accumulation and ER stress, as NRF2, downstream of NUAK1, suppresses antioxidant gene expression [263]

Case presentation A 45-year-old Sinhalese female with a background of diabetes mellitus, hypertension, dyslipidemia, and endometriosis presented with progressive dyspnea

Thus, the increase in H 2 O 2 production for the combinations after 24 hours reflects the enrichment analysis of the proteomics data, which indicate enhanced ROS production and less ROS removal ( Figure 7B )

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Glutathione is often referred to as the master antioxidant because it increases and regenerates other antioxidants , such as vitamin C and CoQ10