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Progress should be tracked with symptoms and function changes

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The nasal route theoretically offers direct nose-to-brain transport via the olfactory nerve pathway, bypassing the blood-brain barrier

mRNA-4157 monotherapy reliably elicited de novo and augmented preexisting T-cell responses to the targeted neoantigens

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As a fixed-dose combination, CagriSema was assessed in two phase 3 studies (REDEFINE 1 and 2), resulting in significant and clinically relevant reductions in body weight compared with placebo in adults with overweight or obesity, with [8] or without type 2 diabetes [9]