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Thus, high GE (HGE) and high GI (HGI) neurons increase or decrease their frequency of potential actions, respectively, in response to increases in interstitial glucose from 5 to 20 mM, although these neurons are still not thoroughly characterized, and there are doubts about their physiological significance

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Gradual dose titration represents the most important preventive measure, allowing physiologic adaptation to gastric emptying effects

The glucagon component, in particular, helps explain why some patients respond differently to GLP-1 therapy, and why medications sometimes stop working

Look for non-comedogenic items, which means they're formulated not to clog poresa critical factor for acne-prone skin

Some patients find that injecting in the evening minimizes nausea during waking hours, since side effects often peak 24 hours post-injection