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This is in contrast with a previous report that showed mTORC1 inhibition activated the ISR 24

Epithalons connection to pineal gland biology and circadian rhythm regulation makes the nighttime window the correct one pharmacologically

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Diabetes Mellitus (DM) DM is a metabolic disease characterized by long-term hyperglycemia, leading to serious complications such as microangiopathy and macroangiopathy, significantly increasing mortality [141]

Elevated mitochondrial lipid peroxidation was also detected under these conditions (Fig