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Mol Cell Endocrinol (2009) 297:13740

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Month 1 Summary: What Was Accomplished Weight loss: 2-4 pounds average (1-2% of starting weight) Appetite change: 60-70% report noticeable suppression Side effects: Mild to moderate in 40% of people, minimal in 60% Discontinuation rate: 3-5% stop during month 1 (lowest attrition period) Psychological state: Hopeful but impatient for faster results Key achievement: Body adapted to medication without major complications Reality check: Month 1 is the easiest month

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