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Weiland et al

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It also modulates metalloproteinase (MMP) activity and their inhibitors (TIMPs), influencing not just the production of new matrix but the breakdown and remodeling of existing tissue

These logistical factors increase operational costs and are reflected in pricing

Together they cover more of the repair cascade local rebuilding on one side, cell mobilisation and remodelling on the other

For some instance, PN can even manifest in spite of having normal vitamin levels and despite receiving an appropriate Vit B12 replacement therapy (Uncini et al