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10.1016/j.sbi.2017.10.002

Data from in vivo study also revealed that a high-fat diet accelerates the proliferation of prostate tumors and increased M2/M1 macrophage ratio and myeloid-derived suppressor cells fraction via interleukin (IL)-6/phospho-signal transducer and activator of transcription 3 (pSTAT3) signaling [43]

Recently, Yoon et al

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In summary, maintaining oocyte quality and delaying reproductive aging requires a strategy that connects advanced biomedical methods with environmental prevention and lifestyle optimization

When your animal is doing better you may try reducing dosages to twice daily and see how they do with that schedule