Poor sleep disrupts hormonal balance, increasing hunger-related hormones like ghrelin and stress hormones like cortisol
For pharmacy practice, this translates to complex polypharmacy, adherence challenges, and a need for careful medicines optimisation to avoid iatrogenic weight gain, ie, weight gain caused by medicines such as antidepressants
A randomized controlled trial in 2018 showed that omega-3 supplementation altered gene expression of the following genes
A human glucagon-like peptide-1 receptor polymorphism results in reduced agonist responsiveness
They do not feel thirsty even though they are dehydrated
26 Certain GLP-1 agonist drugs have been associated with a significantly increased risk of depression and anxiety, 27 highlighting an emerging need for complimentary therapies to support patients mental and emotional health while undergoing pharmaceutical GLP-1 therapy