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Oral GLP-1 receptor agonists and combinations of entero-pancreatic hormones as treatments for adults with type 2 diabetes: where are we now

As far as intestinal phase II drug metabolism is concerned, UGT1A, UGT2B7 and UGT2B15 and SULT1A were shown to be expressed with functional relevance for many drugs, although little quantitative data is available so far (Zarth et al., 2015)

The hAMY 3 R cells were cultured in growth medium consisting of DMEM (Gibco, #31966-021) supplemented with 10% v/v FBS (Gibco, #16140-071), 1% v/v Penicillin-Streptomycin (Gibco, #15140-122), 0.5 mg/mL Geneticin G418 (Gibco, #10131-027), 0.4 mg/mL Hygromycin (Invitrogen, #10687010) and 250 nM Methotrexate (Sigma, A6770)

this means that tissue loses 3 g of GSH a day

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Glutathione steps in to "mop up" these molecules before they can do harm