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The majority of hepatotoxins damage centrilobular hepatocytes, most probably as a result of oxidative activation to electrophilic intermediates by the CYP isoforms located in the centrilobular region (Lindros 1997)

However, some patients may experience a rapid progression over several days

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According to the results of preclinical studies, NAR has a wide range of biological and pharmacological effects involving anticarcinogenic properties (144, 145)