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[3] [5] For patients with LDL-C 190 mg/dL, high-intensity statins are first-line therapy, with consideration of ezetimibe, bempedoic acid, or PCSK9 inhibitors for additional lowering

10.3389/fphar.2021.712876 22 LiuJ.DuJ.LiY.WangF.SongD.LinJ.et al (2022)

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Together, these observations further support that DMF mediates gene locus-specific regulatory mechanism in an NRF2, DNA hydroxymethylation dependent or both to produce protective effect against ferroptosis in SCD