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User 19 ran 500mcg twice daily for 13 weeks across a chronic multi-injury case involving a 10-year back injury and a 4-year shoulder injury, adding GHK-Cu, ipamorelin, and CJC-1295 to the protocol, and reported 90 percent pain relief after one cycle

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A 2019 review in the Journal of Physiology noted that "IGF-1 signalling and mechanical loading converge on mTORC1 to regulate skeletal muscle protein synthesis, and the relative contribution of each remains an active area of investigation" [6]

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