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As per this study, hydromethylthionine failed to achieve primary efficacy endpoints in terms of slowing disease progression at doses of 150-250 mg daily

Convenience is higher, but penetration and systemic effects are limited

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10.1128/MMBR.66.2.250-271.2002 Microbiol

We therefore initiated treatment with BSO in the drinking water for both male and female -Myc mice at P21 and maintained it until 8 months of age, unless humane endpoints were reached

2022;10:e4469