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In multiple organisms, cellular NAD+ levels drop with age, which correlates with the onset of age-related conditions, including metabolic disorders, neurodegeneration, and cardiovascular problems

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This triple-mode protection persisted throughout the three-month drinking period

All animal studies conducted primarily in rats and mice

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J Med Chem 64:216232 Alizadeh AM, Faghihi M, Khori V, Sohanaki H, Pourkhalili K, Mohammadghasemi F, Mohsenikia MJP (2012) Oxytocin protects cardiomyocytes from apoptosis induced by ischemiareperfusion in rat heart: role of mitochondrial ATP-dependent potassium channel and permeability transition pore