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Utilization management is a set of strategies used by insurers to ensure costly drugs such as GLP-1s are used safely, appropriately and cost-effectively

Some clinicians recommend reducing to the lowest effective dose for several weeks while intensifying behavioral interventions, though this approach lacks formal validation

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As real-world data accumulate, a clearer understanding of GLP-1 dermatologic effects will continue to emerge

The widespread acceptance of metformin evolved after the realization that lactic acidosis was not a major problem in individuals with normal renal function

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