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1mg dose: 8.7% average weight loss 4mg dose: 15.2% average weight loss 8mg dose: 21.1% average weight loss 12mg dose: 24.2% average weight loss Placebo: 2.1% average weight loss For practical context, a person starting at 220 pounds would lose approximately 53 pounds at the highest dose over 48 weeks

model (Whelan and Goldman, 2001)

reported that glucagon-induced insulin secretion was inhibited by Exendin 9-39 in purified rat beta-cells (28)