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Designed solely for parenteral use (drug administration by intravenous, intramuscular, or subcutaneous injection) following the addition of drugs that require dilution or must be dissolved in an aqueous vehicle prior to injecting

Animal studies show that direct BDNF infusion into the hippocampus produces antidepressant effects, while blocking BDNF signaling prevents antidepressants from working

Research comparing these approaches head-to-head remains limited, leaving the choice to researcher preference and practical considerations

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In aged skeletal muscle models, NNMT inhibitor treatment increased proliferating/active muscle stem cells by 60-75% following injury, myofiber cross-sectional area increased 1.8-fold at one week post-injury with high-dose treatment, and peak torque of injured muscle increased by 67% compared to control (p = 0.033), with no untoward systemic toxicity observed in plasma chemistry markers (Neelakantan et al., 2019)