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Diagnosis requires extreme fatigue lasting at least 6 months plus at least four additional symptoms: unrefreshing sleep, cognitive impairment ("brain fog"), muscle pain, joint pain, sore throat, tender lymph nodes, or new headaches

The role of zinc in modulating Tregs is another key factor in its immunoregulatory effects

Common biological features of chronic injury Microvascular limitation: the tissue is under-perfused, which slows nutrient delivery and waste removal Inflammatory persistence: cytokine signaling stays elevated and disrupts remodeling Disorganized collagen: collagen exists, but it is poorly aligned, weak, or prone to reinjury Mechanical mismatch: loads exceed tissue capacity due to weakness, compensation, or instability Neurogenic sensitivity: irritated tissues and nerves amplify pain signals even when imaging is normal In other words, chronic injuries do not usually need one intervention