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As oxidizing agents, ROS interfere with intracellular functions, being capable of damaging various cellular elements, including cell membranes, proteins, lipids and nucleic acids, and ultimately resulting in mitochondrial dysfunction and loss of enzymatic activity (19, 20)

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Kagan VE, Mao G, Qu F, Angeli JP, Doll S, Croix CS, Dar HH, Liu B et al (2017) Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

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Limited intervention studies (highlighted in 8) have not convincingly demonstrated a potential anti-inflammatory effect of -tocopherol in humans