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Mice lacking SCARF1 develop lupus-like symptoms, including nephritis and dermatitis, driven by defective phagocytosis of PS- and C1q-labeled apoptotic cells (328)

This increase was not associated with adverse cardiac events

MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff

A major challenge in diagnosing IC/BPS is its heterogeneity, with different subtypes exhibiting variations in genetics, histology, symptomatology and epidemiology, complicating the diagnostic process