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Approaches to restore the antitumor function of exhausted CD8 + T cells by remodeling mitochondrial metabolism, dynamics, and biogenesis have been shown to be effective, suggesting that mitochondria may be a potential target for future cancer therapies

While this concept is undoubtedly real, what influence it actually exerts on disease is unclear

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Yamatani K, Watanabe T, Saito K, Maiti A, Yamashita S, Khasawneh A, Paran FJ, Hayes K, Borthakur G, Harman JR, Kimura S, DiNardo CD, Milne TA, Andreeff M , Tabe Y, and Konopleva MY

Buksh, B