Melatonin is an indolic compound with lipophilic properties derived from the amino acid tryptophan, which is taken up by pinealocytes from the peripheral circulation and transformed into melatonin through the action of four participating enzymes [Figure 1]
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Increasing levels of this much-needed antioxidant are helping many feel relief from anxiety
Dietary deficiency may be treated with oral cyanocobalamin 50150 g or 1,000 g daily until corrected
However, excessive amounts of the vitamin are unnecessary
The Lamming lab is supported in part by the NIA (AG056771, AG062328, AG061635, AG081482, AG084156, and AG094153 to D.W.L.), the NIDDK (DK125859 to D.W.L