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472 FletcherMAZengXRMaherKLevisSHurwitzBAntoniMet al

Limitations of the study are acknowledged including, but not limited to, small sample size due to high dropout rate, combined with high variability of GCGR occupancy, unknown changes in GCGR density and the relevance of low receptor occupancy in terms of clinical efficacy

Chronic conditions may require monthly lifelong therapy

Such studies support the rationale for testing GHR antagonism in cancer, but only a small number of preclinical studies have used pegvisomant in an oncology setting