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Notably, ASD is the most common heritable neurodevelopmental disorder, with heritability estimates of approximately 80% (153)

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Following LPS stimulation, PRMT1-3 have been shown to methylate TLR4 and IRF3, with PRMT2 having the most prominent impact (Figure 8)

Likewise, sex differences in the way some of these drugs are absorbed and metabolized has been noted 37 , though we did not observe any differences in L2-Cmu PK or exposure levels between male and female animals