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In a meta-analysis encompassing 24 randomized controlled trials involving patients with metabolic diseases, ALA was observed to enhance glucose homeostasis (resulting in lower fasting blood glucose, insulin levels, HOMA-IR, and HbA1c) and improve the lipid profile (leading to reductions in triglycerides, total cholesterol, and LDL-C) [208]

23 PATHOGENESIS The exact pathogenesis of SIM occurrence in the distal oesophagus is not known

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