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Cartilage degeneration was scored using the Yoshimi scale, which ranges from 0, defined as normal cartilage, to 5, defined as complete loss of cartilage

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Additionally, behavioral changes in the 6-OHDA mouse model were reversed by the PI3K/Akt signaling pathway (Zhang et al., 2017a), and the reduced number of dopaminergic cells and the levels of dopamine and its metabolites DOPAC and HVA were restored (Datla et al., 2007) when treated with PCs

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