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It is not entirely clear how ALLO, which is a positive allosteric modulator of GABAergic neurotransmission, acts to improve memory function in this patient population, but it has been suggested that stress-induced changes in GABA receptor expression levels are likely to play a role in the etiology of depression

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Moreover, the applicant added that the participants demonstrated functional recovery of the ulnar nerve as measured by improvements in grip strength (68.4 percent of participants) and sensory testing (63.2 percent of participants) from baseline to 6 months