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Antifibrotic therapy for fibrotic lung disease beyond idiopathic pulmonary fibrosis

The medication is absolutely contraindicated with nitrates, amyl nitrite ('poppers'), or riociguat due to risk of severe, potentially life-threatening hypotension

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These analyses further strengthen the credibility of the associations described by multivariate regression analysis (Table 1)

In addition to killing microorganisms, 92 ROS is capable of activating NE and MPO in neutrophils 93 and interacting with the nucleus without restraint, in which serine proteases and NE cleave histones to promote chromatin decondensation

doi: 10.1186/s12970-015-0090-y