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Prognosis A long-term follow up study of 28 patients with glutathione synthetase deficiency has showed that the factors most predictive of survival and long-term outcome are early diagnosis, correction of acidosis and early supplementation with vitamin C and vitamin E [19]

Protein synthesis increases, amino acids enter muscle tissue more efficiently, and damaged fibers repair faster

Additional research highlights anti-inflammatory and antioxidant signaling, including observed reductions in TNF- alongside support for stem cell viability

Note that after 58 hr of fasting, the average levels of 2-HB and 3-HB in four volunteers showed further increases (13.7- and 55.4-fold for 2-HB and 3-HB, respectively), indicating that blood concentrations of 2- and 3-HB after prolonged fasting reach exceedingly high concentrations (~5 mM 3-HB)

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